In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repur...
In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH 4 Therapeutics
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Switzerland
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English
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Switzerland
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Contents
The GTP cyclohydrolase 1 enzyme (GTPCH1) is the rate-limiting enzyme of the tetrahydrobiopterin (BH
) biosynthetic pathway. Physiologically, BH
plays a crucial role as an essential cofactor for the production of catecholamine neurotransmitters, including epinephrine, norepinephrine and dopamine, as well as the gaseous signaling molecule, nitr...
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Full title
In Silico Investigation of the Human GTP Cyclohydrolase 1 Enzyme Reveals the Potential of Drug Repurposing Approaches towards the Discovery of Effective BH 4 Therapeutics
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TN_cdi_pubmed_primary_36674724
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36674724
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E-ISSN
1422-0067
DOI
10.3390/ijms24021210
