Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharma...
Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal E max regressions
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Author / Creator
Publisher
Germany
Journal title
Language
English
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Publisher
Germany
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Scope and Contents
Contents
This study aimed at characterizing indotecan population pharmacokinetics and explore the indotecan-neutropenia relationship in patients with solid tumors.
Population pharmacokinetics were assessed using nonlinear mixed-effects modeling of concentration data from two first-in-human phase 1 trials evaluating different dosing schedules of indotecan...
Alternative Titles
Full title
Evaluating the indotecan-neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal E max regressions
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Record Identifier
TN_cdi_pubmed_primary_36813886
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_36813886
Other Identifiers
E-ISSN
1432-0843
DOI
10.1007/s00280-023-04509-8
