Heart failure-induced cognitive dysfunction is mediated by intracellular Ca 2+ leak through ryanodin...
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca 2+ leak through ryanodine receptor type 2
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Author / Creator
Publisher
United States
Journal title
Language
English
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Publication information
Publisher
United States
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Scope and Contents
Contents
Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle dysfunction, its role in CD in HF remains unclear. Here, we show in hippocampal neurons from individuals and mice with HF that the RyR2/intracellular Ca
release c...
Alternative Titles
Full title
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca 2+ leak through ryanodine receptor type 2
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Record Identifier
TN_cdi_pubmed_primary_37429912
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_37429912
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E-ISSN
1546-1726
DOI
10.1038/s41593-023-01377-6
