Vitamin B 12 is a limiting factor for induced cellular plasticity and tissue repair
Vitamin B 12 is a limiting factor for induced cellular plasticity and tissue repair
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Author / Creator
Kovatcheva, Marta , Melendez, Elena , Chondronasiou, Dafni , Pietrocola, Federico , Bernad, Raquel , Caballe, Adrià , Junza, Alexandra , Capellades, Jordi , Holguín-Horcajo, Adrián , Prats, Neus , Durand, Sylvere , Rovira, Meritxell , Yanes, Oscar , Stephan-Otto Attolini, Camille , Kroemer, Guido and Serrano, Manuel
Publisher
Germany
Journal title
Language
English
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Publisher
Germany
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Scope and Contents
Contents
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its metabolic requirements. Here we show that OSKM reprogramming in mice causes a global depletion of vitamin B
and molecular hallmarks of methionine starvation. Supplementatio...
Alternative Titles
Full title
Vitamin B 12 is a limiting factor for induced cellular plasticity and tissue repair
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Author / Creator
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Record Identifier
TN_cdi_pubmed_primary_37973897
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_37973897
Other Identifiers
E-ISSN
2522-5812
DOI
10.1038/s42255-023-00916-6
