Redox regulation of m 6 A methyltransferase METTL3 in β-cells controls the innate immune response in...
Redox regulation of m 6 A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
About this item
Full title
Author / Creator
De Jesus, Dario F , Zhang, Zijie , Brown, Natalie K , Li, Xiaolu , Xiao, Ling , Hu, Jiang , Gaffrey, Matthew J , Fogarty, Garrett , Kahraman, Sevim , Wei, Jiangbo , Basile, Giorgio , Rana, Tariq M , Mathews, Clayton , Powers, Alvin C , Parent, Audrey V , Atkinson, Mark A , Dhe-Paganon, Sirano , Eizirik, Decio L , Qian, Wei-Jun , He, Chuan and Kulkarni, Rohit N
Publisher
England
Journal title
Language
English
Formats
Publication information
Publisher
England
More information
Scope and Contents
Contents
Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we report that
-methyladenosine (m
A) is an adaptive β-cell safeguard mechanism that controls the amplitude and duration of the antiviral innate immune response at T1D onset....
Alternative Titles
Full title
Redox regulation of m 6 A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Authors, Artists and Contributors
Author / Creator
Zhang, Zijie
Brown, Natalie K
Li, Xiaolu
Xiao, Ling
Hu, Jiang
Gaffrey, Matthew J
Fogarty, Garrett
Kahraman, Sevim
Wei, Jiangbo
Basile, Giorgio
Rana, Tariq M
Mathews, Clayton
Powers, Alvin C
Parent, Audrey V
Atkinson, Mark A
Dhe-Paganon, Sirano
Eizirik, Decio L
Qian, Wei-Jun
He, Chuan
Kulkarni, Rohit N
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_38409327
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_38409327
Other Identifiers
E-ISSN
1476-4679
DOI
10.1038/s41556-024-01368-0
