Basic Science and Pathogenesis
Basic Science and Pathogenesis
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United States
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English
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United States
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Apolipoprotein E4 (APOE4), a common variant of APOE, is a major genetic risk factor for Alzheimer's disease (AD), but APOE4 carriers do not always develop AD. Several large-scale genetic studies have identified a common haplotype of the aging factor klotho that modify disease risk in APOE4 carriers. In humans, klothoharbors two common missense vari...
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Basic Science and Pathogenesis
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TN_cdi_pubmed_primary_39750755
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_39750755
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E-ISSN
1552-5279
DOI
10.1002/alz.090967