A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase
A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and targets the p53 tumor-suppressor protein for ubiquitin-mediated proteolysis. E6-AP is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme i...
Alternative Titles
Full title
A Family of Proteins Structurally and Functionally Related to the E6-AP Ubiquitin-Protein Ligase
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_7708685
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_7708685
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.92.7.2563
