Tissues of MSH2-Deficient Mice Demonstrate Hypermutability on Exposure to a DNA Methylating Agent
Tissues of MSH2-Deficient Mice Demonstrate Hypermutability on Exposure to a DNA Methylating Agent
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Publisher
United States: National Academy of Sciences of the United States of America
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Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Contents
The mutational response of mismatch repair-deficient animals to the alkylating agent N-methyl-N-nitrosourea was evaluated by using a transgenic lacI reporter system. Although the mutations detected in MSH2 heterozygotes were similar to those of controls, MSH2-/-animals demonstrated striking increases in mutation frequency in response to this agent....
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Full title
Tissues of MSH2-Deficient Mice Demonstrate Hypermutability on Exposure to a DNA Methylating Agent
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TN_cdi_pubmed_primary_9448296
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_9448296
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.95.3.1126
