A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for no...
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
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Author / Creator
VA Million Veteran Program , Geisinger-Regeneron DiscovEHR Collaboration , EPoS Consortium , Regeneron Genetics Center , Vujkovic, Marijana , Ramdas, Shweta , Lorenz, Kim M. , Guo, Xiuqing , Darlay, Rebecca , Cordell, Heather J. , He, Jing , Gindin, Yevgeniy , Chung, Chuhan , Myers, Robert P. , Schneider, Carolin V. , Park, Joseph , Lee, Kyung Min , Serper, Marina , Carr, Rotonya M. , Kaplan, David E. , Haas, Mary E. , MacLean, Matthew T. , Witschey, Walter R. , Zhu, Xiang , Tcheandjieu, Catherine , Kember, Rachel L. , Kranzler, Henry R. , Verma, Anurag , Giri, Ayush , Klarin, Derek M. , Sun, Yan V. , Huang, Jie , Huffman, Jennifer E. , Creasy, Kate Townsend , Hand, Nicholas J. , Liu, Ching-Ti , Long, Michelle T. , Yao, Jie , Budoff, Matthew , Tan, Jingyi , Li, Xiaohui , Lin, Henry J. , Chen, Yii-Der Ida , Taylor, Kent D. , Chang, Ruey-Kang , Krauss, Ronald M. , Vilarinho, Silvia , Brancale, Joseph , Nielsen, Jonas B. , Locke, Adam E. , Jones, Marcus B. , Verweij, Niek , Baras, Aris , Reddy, K. Rajender , Neuschwander-Tetri, Brent A. , Schwimmer, Jeffrey B. , Sanyal, Arun J. , Chalasani, Naga , Ryan, Kathleen A. , Mitchell, Braxton D. , Gill, Dipender , Wells, Andrew D. , Manduchi, Elisabetta , Saiman, Yedidya , Mahmud, Nadim , Miller, Donald R. , Reaven, Peter D. , Phillips, Lawrence S. , Muralidhar, Sumitra , DuVall, Scott L. , Lee, Jennifer S. , Assimes, Themistocles L. , Pyarajan, Saiju , Cho, Kelly , Edwards, Todd L. , Damrauer, Scott M. , Wilson, Peter W. , Gaziano, J. Michael , O’Donnell, Christopher J. , Khera, Amit V. , Grant, Struan F. A. , Brown, Christopher D. , Tsao, Philip S. , Saleheen, Danish , Lotta, Luca A. , Bastarache, Lisa , Anstee, Quentin M. , Daly, Ann K. , Meigs, James B. , Rotter, Jerome I. , Lynch, Julie A. , Rader, Daniel J. , Voight, Benjamin F. and Chang, Kyong-Mi
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,1...
Alternative Titles
Full title
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation
Authors, Artists and Contributors
Author / Creator
Geisinger-Regeneron DiscovEHR Collaboration
EPoS Consortium
Regeneron Genetics Center
Vujkovic, Marijana
Ramdas, Shweta
Lorenz, Kim M.
Guo, Xiuqing
Darlay, Rebecca
Cordell, Heather J.
He, Jing
Gindin, Yevgeniy
Chung, Chuhan
Myers, Robert P.
Schneider, Carolin V.
Park, Joseph
Lee, Kyung Min
Serper, Marina
Carr, Rotonya M.
Kaplan, David E.
Haas, Mary E.
MacLean, Matthew T.
Witschey, Walter R.
Zhu, Xiang
Tcheandjieu, Catherine
Kember, Rachel L.
Kranzler, Henry R.
Verma, Anurag
Giri, Ayush
Klarin, Derek M.
Sun, Yan V.
Huang, Jie
Huffman, Jennifer E.
Creasy, Kate Townsend
Hand, Nicholas J.
Liu, Ching-Ti
Long, Michelle T.
Yao, Jie
Budoff, Matthew
Tan, Jingyi
Li, Xiaohui
Lin, Henry J.
Chen, Yii-Der Ida
Taylor, Kent D.
Chang, Ruey-Kang
Krauss, Ronald M.
Vilarinho, Silvia
Brancale, Joseph
Nielsen, Jonas B.
Locke, Adam E.
Jones, Marcus B.
Verweij, Niek
Baras, Aris
Reddy, K. Rajender
Neuschwander-Tetri, Brent A.
Schwimmer, Jeffrey B.
Sanyal, Arun J.
Chalasani, Naga
Ryan, Kathleen A.
Mitchell, Braxton D.
Gill, Dipender
Wells, Andrew D.
Manduchi, Elisabetta
Saiman, Yedidya
Mahmud, Nadim
Miller, Donald R.
Reaven, Peter D.
Phillips, Lawrence S.
Muralidhar, Sumitra
DuVall, Scott L.
Lee, Jennifer S.
Assimes, Themistocles L.
Pyarajan, Saiju
Cho, Kelly
Edwards, Todd L.
Damrauer, Scott M.
Wilson, Peter W.
Gaziano, J. Michael
O’Donnell, Christopher J.
Khera, Amit V.
Grant, Struan F. A.
Brown, Christopher D.
Tsao, Philip S.
Saleheen, Danish
Lotta, Luca A.
Bastarache, Lisa
Anstee, Quentin M.
Daly, Ann K.
Meigs, James B.
Rotter, Jerome I.
Lynch, Julie A.
Rader, Daniel J.
Voight, Benjamin F.
Chang, Kyong-Mi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10024253
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10024253
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-022-01078-z
