Human PRPS1 filaments stabilize allosteric sites to regulate activity
Human PRPS1 filaments stabilize allosteric sites to regulate activity
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a spectrum of diseases. Here we determine structures of human PRPS1 filaments in active and inhibited states, with...
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Full title
Human PRPS1 filaments stabilize allosteric sites to regulate activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10033377
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10033377
Other Identifiers
ISSN
1545-9993,1545-9985
E-ISSN
1545-9985
DOI
10.1038/s41594-023-00921-z
