Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblast...
Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma
About this item
Full title
Author / Creator
Han, Qi-lei , Zhang, Xiang-lei , Ren, Peng-xuan , Mei, Liang-he , Lin, Wei-hong , Wang, Lin , Cao, Yu , Li, Kai and Bai, Fang
Publisher
Singapore: Springer Nature Singapore
Journal title
Language
English
Formats
Publication information
Publisher
Singapore: Springer Nature Singapore
Subjects
More information
Scope and Contents
Contents
Neuroblastoma is the most common and deadliest tumor in infancy. WDR5 (WD Repeat Domain 5), a critical factor supporting an N-myc transcriptional complex via its WBM site and interacting with chromosome via its WIN site, promotes the progression of neuroblastoma, thus making it a potential anti-neuroblastoma drug target. So far, a few WIN site inhi...
Alternative Titles
Full title
Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10043273
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10043273
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/s41401-022-00999-z
