SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
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Publisher
Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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Contents
Loss of function of the succinate dehydrogenase complex characterizes 20–40% of all KIT/PDGFRA-negative GIST. Approximately half of SDH-deficient GIST patients lack SDHx mutations and are caused by a hypermethylation of the SDHC promoter, which causes the repression of SDHC transcription and depletion of SDHC protein levels through a mechanism desc...
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Full title
SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10048394
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10048394
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ISSN
2073-4425
E-ISSN
2073-4425
DOI
10.3390/genes14030646
