Generation of a p21 Reporter Mouse and Its Use to Identify and Eliminate p21high Cells In Vivo
Generation of a p21 Reporter Mouse and Its Use to Identify and Eliminate p21high Cells In Vivo
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Author / Creator
Yi, Zimei , Ren, Le , Wei, Yu , Chen, Siyi , Zhao, Jiechen , Zhu, Jiayu and Wu, Junhua
Publisher
Basel: MDPI AG
Journal title
Language
English
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Publisher
Basel: MDPI AG
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Contents
P21 and p16 have been identified as inducers of senescence. Many transgenic mouse models have been developed to target cells expressing high levels of p16Ink4a (p16high) and investigate their potential contribution to tissue dysfunction in aging, obesity, and other pathological conditions. However, the specific roles of p21 in various senescence-dr...
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Full title
Generation of a p21 Reporter Mouse and Its Use to Identify and Eliminate p21high Cells In Vivo
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10051249
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10051249
Other Identifiers
ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms24065565
