Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
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Author / Creator
Duperron, Marie-Gabrielle , Knol, Maria J. , Le Grand, Quentin , Evans, Tavia E. , Mishra, Aniket , Tsuchida, Ami , Roshchupkin, Gennady , Konuma, Takahiro , Trégouët, David-Alexandre , Romero, Jose Rafael , Frenzel, Stefan , Luciano, Michelle , Hofer, Edith , Bourgey, Mathieu , Dueker, Nicole D. , Delgado, Pilar , Hilal, Saima , Tankard, Rick M. , Dubost, Florian , Shin, Jean , Saba, Yasaman , Armstrong, Nicola J. , Bordes, Constance , Bastin, Mark E. , Beiser, Alexa , Brodaty, Henry , Bülow, Robin , Carrera, Caty , Chen, Christopher , Cheng, Ching-Yu , Deary, Ian J. , Gampawar, Piyush G. , Himali, Jayandra J. , Jiang, Jiyang , Kawaguchi, Takahisa , Li, Shuo , Macalli, Melissa , Marquis, Pascale , Morris, Zoe , Muñoz Maniega, Susana , Miyamoto, Susumu , Okawa, Masakazu , Paradise, Matthew , Parva, Pedram , Rundek, Tatjana , Sargurupremraj, Muralidharan , Schilling, Sabrina , Setoh, Kazuya , Soukarieh, Omar , Tabara, Yasuharu , Teumer, Alexander , Thalamuthu, Anbupalam , Trollor, Julian N. , Valdés Hernández, Maria C. , Vernooij, Meike W. , Völker, Uwe , Wittfeld, Katharina , Wong, Tien Yin , Wright, Margaret J. , Zhang, Junyi , Zhao, Wanting , Zhu, Yi-Cheng , Schmidt, Helena , Sachdev, Perminder S. , Wen, Wei , Yoshida, Kazumichi , Joutel, Anne , Satizabal, Claudia L. , Sacco, Ralph L. , Bourque, Guillaume , Lathrop, Mark , Paus, Tomas , Fernandez-Cadenas, Israel , Yang, Qiong , Mazoyer, Bernard , Boutinaud, Philippe , Okada, Yukinori , Grabe, Hans J. , Mather, Karen A. , Schmidt, Reinhold , Joliot, Marc , Ikram, M. Arfan , Matsuda, Fumihiko , Tzourio, Christophe , Wardlaw, Joanna M. , Seshadri, Sudha , Adams, Hieab H. H. , Debette, Stéphanie , the CHARGE consortium and CHARGE consortium
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk...
Alternative Titles
Full title
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Authors, Artists and Contributors
Author / Creator
Knol, Maria J.
Le Grand, Quentin
Evans, Tavia E.
Mishra, Aniket
Tsuchida, Ami
Roshchupkin, Gennady
Konuma, Takahiro
Trégouët, David-Alexandre
Romero, Jose Rafael
Frenzel, Stefan
Luciano, Michelle
Hofer, Edith
Bourgey, Mathieu
Dueker, Nicole D.
Delgado, Pilar
Hilal, Saima
Tankard, Rick M.
Dubost, Florian
Shin, Jean
Saba, Yasaman
Armstrong, Nicola J.
Bordes, Constance
Bastin, Mark E.
Beiser, Alexa
Brodaty, Henry
Bülow, Robin
Carrera, Caty
Chen, Christopher
Cheng, Ching-Yu
Deary, Ian J.
Gampawar, Piyush G.
Himali, Jayandra J.
Jiang, Jiyang
Kawaguchi, Takahisa
Li, Shuo
Macalli, Melissa
Marquis, Pascale
Morris, Zoe
Muñoz Maniega, Susana
Miyamoto, Susumu
Okawa, Masakazu
Paradise, Matthew
Parva, Pedram
Rundek, Tatjana
Sargurupremraj, Muralidharan
Schilling, Sabrina
Setoh, Kazuya
Soukarieh, Omar
Tabara, Yasuharu
Teumer, Alexander
Thalamuthu, Anbupalam
Trollor, Julian N.
Valdés Hernández, Maria C.
Vernooij, Meike W.
Völker, Uwe
Wittfeld, Katharina
Wong, Tien Yin
Wright, Margaret J.
Zhang, Junyi
Zhao, Wanting
Zhu, Yi-Cheng
Schmidt, Helena
Sachdev, Perminder S.
Wen, Wei
Yoshida, Kazumichi
Joutel, Anne
Satizabal, Claudia L.
Sacco, Ralph L.
Bourque, Guillaume
Lathrop, Mark
Paus, Tomas
Fernandez-Cadenas, Israel
Yang, Qiong
Mazoyer, Bernard
Boutinaud, Philippe
Okada, Yukinori
Grabe, Hans J.
Mather, Karen A.
Schmidt, Reinhold
Joliot, Marc
Ikram, M. Arfan
Matsuda, Fumihiko
Tzourio, Christophe
Wardlaw, Joanna M.
Seshadri, Sudha
Adams, Hieab H. H.
Debette, Stéphanie
the CHARGE consortium
CHARGE consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10115645
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10115645
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X,1744-7933
DOI
10.1038/s41591-023-02268-w
