Aging is associated with a systemic length-associated transcriptome imbalance
Aging is associated with a systemic length-associated transcriptome imbalance
About this item
Full title
Author / Creator
Stoeger, Thomas , Grant, Rogan A. , McQuattie-Pimentel, Alexandra C. , Anekalla, Kishore R. , Liu, Sophia S. , Tejedor-Navarro, Heliodoro , Singer, Benjamin D. , Abdala-Valencia, Hiam , Schwake, Michael , Tetreault, Marie-Pier , Perlman, Harris , Balch, William E. , Chandel, Navdeep S. , Ridge, Karen M. , Sznajder, Jacob I. , Morimoto, Richard I. , Misharin, Alexander V. , Budinger, G. R. Scott and Nunes Amaral, Luis A.
Publisher
United States: Nature Publishing Group
Journal title
Language
English
Formats
Publication information
Publisher
United States: Nature Publishing Group
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More information
Scope and Contents
Contents
Aging is among the most important risk factors for morbidity and mortality. To contribute toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data from multiple studies. Here, we show that transcript length alone explains most transcriptional changes observed with aging in mice and humans. We present three lines of ev...
Alternative Titles
Full title
Aging is associated with a systemic length-associated transcriptome imbalance
Authors, Artists and Contributors
Author / Creator
Grant, Rogan A.
McQuattie-Pimentel, Alexandra C.
Anekalla, Kishore R.
Liu, Sophia S.
Tejedor-Navarro, Heliodoro
Singer, Benjamin D.
Abdala-Valencia, Hiam
Schwake, Michael
Tetreault, Marie-Pier
Perlman, Harris
Balch, William E.
Chandel, Navdeep S.
Ridge, Karen M.
Sznajder, Jacob I.
Morimoto, Richard I.
Misharin, Alexander V.
Budinger, G. R. Scott
Nunes Amaral, Luis A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154227
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154227
Other Identifiers
ISSN
2662-8465
E-ISSN
2662-8465
DOI
10.1038/s43587-022-00317-6
