Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
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Author / Creator
Chen, Jian , Qiu, Shizhen , Li, Wentao , Wang, Kun , Zhang, Yu , Yang, Han , Liu, Baichuan , Li, Guangfei , Li, Li , Chen, Min , Lan, Junjie , Niu, Jiahua , He, Peijie , Cheng, Lei , Fan, Gaofeng , Liu, Xin , Song, Xianmin , Xu, Chenqi , Wu, Haitao and Wang, Haopeng
Publisher
Singapore: Springer Nature Singapore
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Language
English
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Publisher
Singapore: Springer Nature Singapore
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Contents
Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, the molecular mechanism underlying the spontaneous CAR signals remains elusive. Here, we unveil that positively charged patches (PCPs) on the s...
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Full title
Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10156745
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10156745
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ISSN
1748-7838,1001-0602
E-ISSN
1748-7838
DOI
10.1038/s41422-023-00789-0
