Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
About this item
Full title
Author / Creator
Rojas, Luis A. , Sethna, Zachary , Soares, Kevin C. , Olcese, Cristina , Pang, Nan , Patterson, Erin , Lihm, Jayon , Ceglia, Nicholas , Guasp, Pablo , Chu, Alexander , Yu, Rebecca , Chandra, Adrienne Kaya , Waters, Theresa , Ruan, Jennifer , Amisaki, Masataka , Zebboudj, Abderezak , Odgerel, Zagaa , Payne, George , Derhovanessian, Evelyna , Müller, Felicitas , Rhee, Ina , Yadav, Mahesh , Dobrin, Anton , Sadelain, Michel , Łuksza, Marta , Cohen, Noah , Tang, Laura , Basturk, Olca , Gönen, Mithat , Katz, Seth , Do, Richard Kinh , Epstein, Andrew S. , Momtaz, Parisa , Park, Wungki , Sugarman, Ryan , Varghese, Anna M. , Won, Elizabeth , Desai, Avni , Wei, Alice C. , D’Angelica, Michael I. , Kingham, T. Peter , Mellman, Ira , Merghoub, Taha , Wolchok, Jedd D. , Sahin, Ugur , Türeci, Özlem , Greenbaum, Benjamin D. , Jarnagin, William R. , Drebin, Jeffrey , O’Reilly, Eileen M. and Balachandran, Vinod P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients
1
, yet harbours mutation-derived T cell neoantigens that are suitable for vaccines
2
,
3
. Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, we synthesized mRNA neoantigen v...
Alternative Titles
Full title
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
Authors, Artists and Contributors
Author / Creator
Sethna, Zachary
Soares, Kevin C.
Olcese, Cristina
Pang, Nan
Patterson, Erin
Lihm, Jayon
Ceglia, Nicholas
Guasp, Pablo
Chu, Alexander
Yu, Rebecca
Chandra, Adrienne Kaya
Waters, Theresa
Ruan, Jennifer
Amisaki, Masataka
Zebboudj, Abderezak
Odgerel, Zagaa
Payne, George
Derhovanessian, Evelyna
Müller, Felicitas
Rhee, Ina
Yadav, Mahesh
Dobrin, Anton
Sadelain, Michel
Łuksza, Marta
Cohen, Noah
Tang, Laura
Basturk, Olca
Gönen, Mithat
Katz, Seth
Do, Richard Kinh
Epstein, Andrew S.
Momtaz, Parisa
Park, Wungki
Sugarman, Ryan
Varghese, Anna M.
Won, Elizabeth
Desai, Avni
Wei, Alice C.
D’Angelica, Michael I.
Kingham, T. Peter
Mellman, Ira
Merghoub, Taha
Wolchok, Jedd D.
Sahin, Ugur
Türeci, Özlem
Greenbaum, Benjamin D.
Jarnagin, William R.
Drebin, Jeffrey
O’Reilly, Eileen M.
Balachandran, Vinod P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10171177
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10171177
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-023-06063-y
