Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis
Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Extracellular cold-inducible RNA-binding protein (eCIRP) is a key mediator of severity and mortality in sepsis. We found that stimulation of mouse bone marrow-derived neutrophils (BMDNs) with eCIRP generated a distinct neutrophil subpopulation, characterized by cell surface markers of both antigen-presenting cells and aged neutrophils as well as ex...
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Full title
Antigen-presenting aged neutrophils induce CD4+ T cells to exacerbate inflammation in sepsis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10348768
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10348768
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI164585
