IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblas...
IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts
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Author / Creator
Picard, Felix Simon Ruben , Lutz, Veronika , Brichkina, Anna , Neuhaus, Felix , Ruckenbrod, Teresa , Hupfer, Anna , Raifer, Hartmann , Klein, Matthias , Bopp, Tobias , Pfefferle, Petra Ina , Savai, Rajkumar , Prinz, Immo , Waisman, Ari , Moos, Sonja , Chang, Hyun-Dong , Heinrich, Stefan , Bartsch, Detlef K , Buchholz, Malte , Singh, Shiv , Tu, Mengyu , Klein, Lukas , Bauer, Christian , Liefke, Robert , Burchert, Andreas , Chung, Ho-Ryun , Mayer, Philipp , Gress, Thomas M , Lauth, Matthias , Gaida, Matthias and Huber, Magdalena
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Subjects
More information
Scope and Contents
Contents
ObjectivePancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic stroma composed of cancer-associated fibroblasts (CAF) and interspersed immune cells. A non-canonical CD8+ T-cell subpopulation producing IL-17A (Tc17) promotes autoimmunity and has been identified in tumours. Here, we evaluated the Tc17 role in PDAC.Desig...
Alternative Titles
Full title
IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts
Authors, Artists and Contributors
Author / Creator
Lutz, Veronika
Brichkina, Anna
Neuhaus, Felix
Ruckenbrod, Teresa
Hupfer, Anna
Raifer, Hartmann
Klein, Matthias
Bopp, Tobias
Pfefferle, Petra Ina
Savai, Rajkumar
Prinz, Immo
Waisman, Ari
Moos, Sonja
Chang, Hyun-Dong
Heinrich, Stefan
Bartsch, Detlef K
Buchholz, Malte
Singh, Shiv
Tu, Mengyu
Klein, Lukas
Bauer, Christian
Liefke, Robert
Burchert, Andreas
Chung, Ho-Ryun
Mayer, Philipp
Gress, Thomas M
Lauth, Matthias
Gaida, Matthias
Huber, Magdalena
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10359545
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10359545
Other Identifiers
ISSN
0017-5749,1468-3288
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2022-327855
