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The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repress...

The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repress...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10374800

The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repression

About this item

Full title

The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repression

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Journal of cancer research and clinical oncology, 2023-09, Vol.149 (11), p.8267-8277

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Background
Class I selective histone deacetylase inhibitors (HDACi) have been previously demonstrated to not only increase major histocompatibility complex class I surface expression in Merkel cell carcinoma (MCC) cells by restoring the antigen processing and presentation machinery, but also exert anti-tumoral effect by inducing apoptosis. Both...

Alternative Titles

Full title

The HDAC inhibitor domatinostat induces type I interferon α in Merkel cell carcinoma by HES1 repression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10374800

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10374800

Other Identifiers

ISSN

0171-5216,1432-1335

E-ISSN

1432-1335

DOI

10.1007/s00432-023-04733-y

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