Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by t...
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
About this item
Full title
Author / Creator
Giles, Josephine R. , Ngiow, Shin Foong , Manne, Sasikanth , Baxter, Amy E. , Khan, Omar , Wang, Ping , Staupe, Ryan , Abdel-Hakeem, Mohamed S. , Huang, Hua , Mathew, Divij , Painter, Mark M. , Wu, Jennifer E. , Huang, Yinghui Jane , Goel, Rishi R. , Yan, Patrick K. , Karakousis, Giorgos C. , Xu, Xiaowei , Mitchell, Tara C. , Huang, Alexander C. and Wherry, E. John
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Naïve CD8
+
T cells can differentiate into effector (T
eff
), memory (T
mem
) or exhausted (T
ex
) T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capacities and therefore therapeutic potential. The molecular circuitry underl...
Alternative Titles
Full title
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Authors, Artists and Contributors
Author / Creator
Ngiow, Shin Foong
Manne, Sasikanth
Baxter, Amy E.
Khan, Omar
Wang, Ping
Staupe, Ryan
Abdel-Hakeem, Mohamed S.
Huang, Hua
Mathew, Divij
Painter, Mark M.
Wu, Jennifer E.
Huang, Yinghui Jane
Goel, Rishi R.
Yan, Patrick K.
Karakousis, Giorgos C.
Xu, Xiaowei
Mitchell, Tara C.
Huang, Alexander C.
Wherry, E. John
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10408358
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10408358
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-022-01338-4
