Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme
Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
RNA-guided type V CRISPR–Cas12 effectors provide adaptive immunity against mobile genetic elements (MGEs) in bacteria and archaea. Among diverse Cas12 enzymes, the recently identified Cas12m2 (CRISPR–Cas type V-M) is highly compact and has a unique RuvC active site. Although the non-canonical RuvC triad does not permit dsDNA cleavage, Cas12m2 still...
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Full title
Mechanistic and evolutionary insights into a type V-M CRISPR–Cas effector enzyme
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10442227
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10442227
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-023-01042-3
