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Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmeth...

Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmeth...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10487412

Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmethyl-diprenorphine ([ 18 F]FE-DPN) for PET Imaging of Brain Opioid Receptors

About this item

Full title

Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmethyl-diprenorphine ([ 18 F]FE-DPN) for PET Imaging of Brain Opioid Receptors

Publisher

Switzerland: MDPI AG

Journal title

International journal of molecular sciences, 2023-08, Vol.24 (17), p.13152

Language

English

Formats

Publication information

Publisher

Switzerland: MDPI AG

More information

Scope and Contents

Contents

We have established a method for nucleophilic one-pot, two-step radiosynthesis of the popular opioid receptor radioligand 6-
-(2-[
F]fluoroethyl)-6-
-desmethyl-diprenorphine ([
F]FE-DPN) from the novel precursor 6-
-(2-tosyloxyethyl)-6-
-desmethyl- 3-
-trityl-diprenorphine (TE-TDDPN), which we designate as the Henriksen precurs...

Alternative Titles

Full title

Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmethyl-diprenorphine ([ 18 F]FE-DPN) for PET Imaging of Brain Opioid Receptors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10487412

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10487412

Other Identifiers

ISSN

1422-0067,1661-6596

E-ISSN

1422-0067

DOI

10.3390/ijms241713152

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