Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmeth...
Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmethyl-diprenorphine ([ 18 F]FE-DPN) for PET Imaging of Brain Opioid Receptors
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Switzerland: MDPI AG
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English
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Switzerland: MDPI AG
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We have established a method for nucleophilic one-pot, two-step radiosynthesis of the popular opioid receptor radioligand 6-
-(2-[
F]fluoroethyl)-6-
-desmethyl-diprenorphine ([
F]FE-DPN) from the novel precursor 6-
-(2-tosyloxyethyl)-6-
-desmethyl- 3-
-trityl-diprenorphine (TE-TDDPN), which we designate as the Henriksen precurs...
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Full title
Optimization of a Nucleophilic Two-Step Radiosynthesis of 6- O -(2-[ 18 F]fluoroethyl)-6- O -desmethyl-diprenorphine ([ 18 F]FE-DPN) for PET Imaging of Brain Opioid Receptors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10487412
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10487412
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms241713152
