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Pilocytic astrocytoma (PA), the most common pediatric brain tumor, is driven by aberrant mitogen-activated protein kinase signaling most commonly caused by BRAF gene fusions or activating mutations. While 5-year overall survival rates exceed 95%, tumor recurrence or progression constitutes a major clinical challenge in incompletely resecte...

Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma

10.1007/s00401-023-02626-5