The Impact of Drug–Drug Interactions on the Toxicity Profile of Combined Treatment with BRAF and MEK...
The Impact of Drug–Drug Interactions on the Toxicity Profile of Combined Treatment with BRAF and MEK Inhibitors in Patients with BRAF-Mutated Metastatic Melanoma
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Author / Creator
Mezi, Silvia , Botticelli, Andrea , Scagnoli, Simone , Pomati, Giulia , Fiscon, Giulia , De Galitiis, Federica , Di Pietro, Francesca Romana , Verkhovskaia, Sofia , Amirhassankhani, Sasan , Pisegna, Simona , Gentile, Giovanna , Simmaco, Maurizio , Gohlke, Bjoern , Preissner, Robert and Marchetti, Paolo
Publisher
Basel: MDPI AG
Journal title
Language
English
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Publisher
Basel: MDPI AG
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Scope and Contents
Contents
Background: BRAF and MEK inhibition is a successful strategy in managing BRAF-mutant melanoma, even if the treatment-related toxicity is substantial. We analyzed the role of drug–drug interactions (DDI) on the toxicity profile of anti-BRAF/anti-MEK therapy. Methods: In this multicenter, observational, and retrospective study, DDIs were assessed usi...
Alternative Titles
Full title
The Impact of Drug–Drug Interactions on the Toxicity Profile of Combined Treatment with BRAF and MEK Inhibitors in Patients with BRAF-Mutated Metastatic Melanoma
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10526382
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10526382
Other Identifiers
ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers15184587
