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Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels

Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10567936

Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels

About this item

Full title

Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Pflügers Archiv, 2023-11, Vol.475 (11), p.1343-1355

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

The voltage-gated sodium channel Na
V
1.8 is prominently expressed in the soma and axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene
SCN10A
are associated with peripheral pain and autonomic dysfunction. While most disease-associated
SCN10A
variants confer gain-of-function properties to Na

Alternative Titles

Full title

Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10567936

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10567936

Other Identifiers

ISSN

0031-6768

E-ISSN

1432-2013

DOI

10.1007/s00424-023-02856-2

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