The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s...
The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence
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Author / Creator
Jiang, Si-Yuan , Tian, Tian , Yao, Hang , Xia, Xiao-Mei , Wang, Cong , Cao, Lei , Hu, Gang , Du, Ren-Hong and Lu, Ming
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Recent studies provide clues that astrocyte senescence is correlated with Parkinson’s disease (PD) progression, while little is known about the molecular basis for astrocyte senescence in PD. Here, we found that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) was upregulated in senescent astrocytes of PD and aged mice. Strikin...
Alternative Titles
Full title
The cGAS-STING-YY1 axis accelerates progression of neurodegeneration in a mouse model of Parkinson’s disease via LCN2-dependent astrocyte senescence
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10589362
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10589362
Other Identifiers
ISSN
1350-9047,1476-5403
E-ISSN
1476-5403
DOI
10.1038/s41418-023-01216-y
