Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifesp...
Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan
About this item
Full title
Author / Creator
van de Sandt, Carolien E. , Nguyen, Thi H. O. , Gherardin, Nicholas A. , Crawford, Jeremy Chase , Samir, Jerome , Minervina, Anastasia A. , Pogorelyy, Mikhail V. , Rizzetto, Simone , Szeto, Christopher , Kaur, Jasveen , Ranson, Nicole , Sonda, Sabrina , Harper, Alice , Redmond, Samuel J. , McQuilten, Hayley A. , Menon, Tejas , Sant, Sneha , Jia, Xiaoxiao , Pedrina, Kate , Karapanagiotidis, Theo , Cain, Natalie , Nicholson, Suellen , Chen, Zhenjun , Lim, Ratana , Clemens, E. Bridie , Eltahla, Auda , La Gruta, Nicole L. , Crowe, Jane , Lappas, Martha , Rossjohn, Jamie , Godfrey, Dale I. , Thomas, Paul G. , Gras, Stephanie , Flanagan, Katie L. , Luciani, Fabio and Kedzierska, Katherine
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
CD8
+
T cells provide robust antiviral immunity, but how epitope-specific T cells evolve across the human lifespan is unclear. Here we defined CD8
+
T cell immunity directed at the prominent influenza epitope HLA-A*02:01-M1
58–66
(A2/M1
58
) across four age groups at phenotypic, transcriptomic, clonal and functional levels....
Alternative Titles
Full title
Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan
Authors, Artists and Contributors
Author / Creator
Nguyen, Thi H. O.
Gherardin, Nicholas A.
Crawford, Jeremy Chase
Samir, Jerome
Minervina, Anastasia A.
Pogorelyy, Mikhail V.
Rizzetto, Simone
Szeto, Christopher
Kaur, Jasveen
Ranson, Nicole
Sonda, Sabrina
Harper, Alice
Redmond, Samuel J.
McQuilten, Hayley A.
Menon, Tejas
Sant, Sneha
Jia, Xiaoxiao
Pedrina, Kate
Karapanagiotidis, Theo
Cain, Natalie
Nicholson, Suellen
Chen, Zhenjun
Lim, Ratana
Clemens, E. Bridie
Eltahla, Auda
La Gruta, Nicole L.
Crowe, Jane
Lappas, Martha
Rossjohn, Jamie
Godfrey, Dale I.
Thomas, Paul G.
Gras, Stephanie
Flanagan, Katie L.
Luciani, Fabio
Kedzierska, Katherine
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10602853
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10602853
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-023-01633-8
