CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses
CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Virophagy, the selective autophagosomal engulfment and lysosomal degradation of viral components, is crucial for neuronal cell survival and antiviral immunity. However, the mechanisms leading to viral antigen recognition and capture by autophagic machinery remain poorly understood. Here, we identified cyclin-dependent kinase-like 5 (CDKL5), known t...
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Full title
CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10760973
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10760973
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI168544
