Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating...
Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
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Publisher
Singapore: Springer Nature Singapore
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Language
English
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Singapore: Springer Nature Singapore
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Dopaminergic neurons in the substantia nigra (SN) expressing SUR1/Kir6.2 type ATP-sensitive potassium channels (K-ATP) are more vulnerable to rotenone or metabolic stress, which may be an important reason for the selective degeneration of neurons in Parkinson’s disease (PD). Baicalein has shown neuroprotective effects in PD animal models. In this s...
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Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10834402
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10834402
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ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/s41401-023-01187-3
