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APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10863749

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

The
APOE4
allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has the most enriched gene expression in neurodegenerative microglia (MGnD). Here, we show in mice and humans a negative role of microglial APOE4 in the induction of t...

Alternative Titles

Full title

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10863749

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10863749

Other Identifiers

ISSN

1529-2908,1529-2916

E-ISSN

1529-2916

DOI

10.1038/s41590-023-01627-6

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