APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
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Author / Creator
Yin, Zhuoran , Rosenzweig, Neta , Kleemann, Kilian L. , Zhang, Xiaoming , Brandão, Wesley , Margeta, Milica A. , Schroeder, Caitlin , Sivanathan, Kisha N. , Silveira, Sebastian , Gauthier, Christian , Mallah, Dania , Pitts, Kristen M. , Durao, Ana , Herron, Shawn , Shorey, Hannah , Cheng, Yiran , Barry, Jen-Li , Krishnan, Rajesh K. , Wakelin, Sam , Rhee, Jared , Yung, Anthony , Aronchik, Michael , Wang, Chao , Jain, Nimansha , Bao, Xin , Gerrits, Emma , Brouwer, Nieske , Deik, Amy , Tenen, Daniel G. , Ikezu, Tsuneya , Santander, Nicolas G. , McKinsey, Gabriel L. , Baufeld, Caroline , Sheppard, Dean , Krasemann, Susanne , Nowarski, Roni , Eggen, Bart J. L. , Clish, Clary , Tanzi, Rudolph E. , Madore, Charlotte , Arnold, Thomas D. , Holtzman, David M. and Butovsky, Oleg
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The
APOE4
allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has the most enriched gene expression in neurodegenerative microglia (MGnD). Here, we show in mice and humans a negative role of microglial APOE4 in the induction of t...
Alternative Titles
Full title
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints
Authors, Artists and Contributors
Author / Creator
Rosenzweig, Neta
Kleemann, Kilian L.
Zhang, Xiaoming
Brandão, Wesley
Margeta, Milica A.
Schroeder, Caitlin
Sivanathan, Kisha N.
Silveira, Sebastian
Gauthier, Christian
Mallah, Dania
Pitts, Kristen M.
Durao, Ana
Herron, Shawn
Shorey, Hannah
Cheng, Yiran
Barry, Jen-Li
Krishnan, Rajesh K.
Wakelin, Sam
Rhee, Jared
Yung, Anthony
Aronchik, Michael
Wang, Chao
Jain, Nimansha
Bao, Xin
Gerrits, Emma
Brouwer, Nieske
Deik, Amy
Tenen, Daniel G.
Ikezu, Tsuneya
Santander, Nicolas G.
McKinsey, Gabriel L.
Baufeld, Caroline
Sheppard, Dean
Krasemann, Susanne
Nowarski, Roni
Eggen, Bart J. L.
Clish, Clary
Tanzi, Rudolph E.
Madore, Charlotte
Arnold, Thomas D.
Holtzman, David M.
Butovsky, Oleg
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10863749
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10863749
Other Identifiers
ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-023-01627-6