BRAF突变在非小细胞肺癌中的研究进展
BRAF突变在非小细胞肺癌中的研究进展
About this item
Full title
Author / Creator
Publisher
No. 154 Anshan Road, Heping District, Tianjin, PRC, 300052: Editorial board of Chinese Journal of Lung Cancer
Journal title
Language
English
Formats
Publication information
Publisher
No. 154 Anshan Road, Heping District, Tianjin, PRC, 300052: Editorial board of Chinese Journal of Lung Cancer
Subjects
More information
Scope and Contents
Contents
鼠类肉瘤病毒癌基因同源物（V-Raf murine sarcoma viral oncogene homolog B, BRAF）突变是非小细胞肺癌（non-small cell lung cancer, NSCLC）的重要驱动基因之一。BRAF基因编码丝氨酸/苏氨酸蛋白激酶，BRAF突变通常导致其编码蛋白质的活化，从而导致丝裂原活化蛋白激酶激酶（mitogen-activated protein kinase kinase, MEK）信号传导途径的激活。针对BRAF突变或其下游MEK靶向药物的临床应用，为BRAF突变的NSCLC提供了更为针对性及有效的治疗。然而这些方案也存在获益持续时间短、BRAF非V600突变治疗效果差、易耐药等问题，需要新的复合治疗方案来改善。本文就BRAF基因结构特...
Alternative Titles
Full title
BRAF突变在非小细胞肺癌中的研究进展
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10895288
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10895288
Other Identifiers
ISSN
1009-3419
E-ISSN
1999-6187
DOI
10.3779/j.issn.1009-3419.2024.101.01
