Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis
Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis
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Basel, Switzerland: Karger Publishers
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Language
English
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Basel, Switzerland: Karger Publishers
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Background/Aims: The Cl - /HCO 3 - exchanger pendrin and the thiazide-sensitive Na-Cl cotransporter NCC are expressed in the kidney distal nephron and mediate salt absorption. We hypothesized that deletion of pendrin leaves NCC as the major salt absorbing transporter in the distal nephron and therefore enhances salt excretion by hydrochlorothiazide...
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Full title
Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10947751
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10947751
Other Identifiers
ISSN
1420-4096
E-ISSN
1423-0143
DOI
10.1159/000479296
