Principles and methods for transferring polygenic risk scores across global populations
Principles and methods for transferring polygenic risk scores across global populations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait or disease and may become a valuable tool for advancing precision medicine. However, PRSs that are developed in populations of predominantly European genetic ancestries can increase health disparities due to poor predictive performance in individuals of diver...
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Principles and methods for transferring polygenic risk scores across global populations
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10961971
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10961971
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ISSN
1471-0056,1471-0064
E-ISSN
1471-0064
DOI
10.1038/s41576-023-00637-2
