The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
About this item
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)
1
–
7
. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue...
Alternative Titles
Full title
The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10972748
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10972748
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-024-07112-w
