Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing
Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing
About this item
Full title
Author / Creator
Appelbaum, Jacob , Price, April E. , Oda, Kaori , Zhang, Joy , Leung, Wai-Hang , Tampella, Giacomo , Xia, Dong , So, Pauline P.L. , Hilton, Sarah K. , Evandy, Claudya , Sarkar, Semanti , Martin, Unja , Krostag, Anne-Rachel , Leonardi, Marissa , Zak, Daniel E. , Logan, Rachael , Lewis, Paula , Franke-Welch, Secil , Ngwenyama, Njabulo , Fitzgerald, Michael , Tulberg, Niklas , Rawlings-Rhea, Stephanie , Gardner, Rebecca A. , Jones, Kyle , Sanabria, Angelica , Crago, William , Timmer, John , Hollands, Andrew , Eckelman, Brendan , Bilic, Sanela , Woodworth, Jim , Lamble, Adam , Gregory, Philip D. , Jarjour, Jordan , Pogson, Mark , Gustafson, Joshua A. , Astrakhan, Alexander and Jensen, Michael C.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Chimeric antigen receptor (CAR) designs that incorporate pharmacologic control are desirable; however, designs suitable for clinical translation are needed. We designed a fully human, rapamycin-regulated drug product for targeting CD33+ tumors called dimerizaing agent-regulated immunoreceptor complex (DARIC33). T cell products demonstrated target-s...
Alternative Titles
Full title
Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing
Authors, Artists and Contributors
Author / Creator
Price, April E.
Oda, Kaori
Zhang, Joy
Leung, Wai-Hang
Tampella, Giacomo
Xia, Dong
So, Pauline P.L.
Hilton, Sarah K.
Evandy, Claudya
Sarkar, Semanti
Martin, Unja
Krostag, Anne-Rachel
Leonardi, Marissa
Zak, Daniel E.
Logan, Rachael
Lewis, Paula
Franke-Welch, Secil
Ngwenyama, Njabulo
Fitzgerald, Michael
Tulberg, Niklas
Rawlings-Rhea, Stephanie
Gardner, Rebecca A.
Jones, Kyle
Sanabria, Angelica
Crago, William
Timmer, John
Hollands, Andrew
Eckelman, Brendan
Bilic, Sanela
Woodworth, Jim
Lamble, Adam
Gregory, Philip D.
Jarjour, Jordan
Pogson, Mark
Gustafson, Joshua A.
Astrakhan, Alexander
Jensen, Michael C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11060733
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11060733
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI162593
