Oncogenic ETS fusions promote DNA damage and proinflammatory responses via pericentromeric RNAs in e...
Oncogenic ETS fusions promote DNA damage and proinflammatory responses via pericentromeric RNAs in extracellular vesicles
About this item
Full title
Author / Creator
Ruzanov, Peter , Evdokimova, Valentina , Pachva, Manideep C , Minkovich, Alon , Zhang, Zhenbo , Langman, Sofya , Gassmann, Hendrik , Thiel, Uwe , Orlic-Milacic, Marija , Zaidi, Syed H , Peltekova, Vanya , Heisler, Lawrence E , Sharma, Manju , Cox, Michael E , McKee, Trevor D , Zaidi, Mark , Lapouble, Eve , McPherson, John D , Delattre, Olivier , Radvanyi, Laszlo , Burdach, Stefan Eg , Stein, Lincoln D and Sorensen, Poul H
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Aberrant expression of the E26 transformation-specific (ETS) transcription factors characterizes numerous human malignancies. Many of these proteins, including EWS:FLI1 and EWS:ERG fusions in Ewing sarcoma (EwS) and TMPRSS2:ERG in prostate cancer (PCa), drive oncogenic programs via binding to GGAA repeats. We report here that both EWS:FLI1 and ERG...
Alternative Titles
Full title
Oncogenic ETS fusions promote DNA damage and proinflammatory responses via pericentromeric RNAs in extracellular vesicles
Authors, Artists and Contributors
Author / Creator
Evdokimova, Valentina
Pachva, Manideep C
Minkovich, Alon
Zhang, Zhenbo
Langman, Sofya
Gassmann, Hendrik
Thiel, Uwe
Orlic-Milacic, Marija
Zaidi, Syed H
Peltekova, Vanya
Heisler, Lawrence E
Sharma, Manju
Cox, Michael E
McKee, Trevor D
Zaidi, Mark
Lapouble, Eve
McPherson, John D
Delattre, Olivier
Radvanyi, Laszlo
Burdach, Stefan Eg
Stein, Lincoln D
Sorensen, Poul H
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11060741
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11060741
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI169470
