Cell type-specific roles of APOE4 in Alzheimer disease
Cell type-specific roles of APOE4 in Alzheimer disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The
ɛ4
allele of the apolipoprotein E gene (
APOE
), which translates to the APOE4 isoform, is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS, APOE is produced by a variety of cell types under different conditions, posing a challenge for studying its roles in AD pathogenesis. However, through pow...
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Full title
Cell type-specific roles of APOE4 in Alzheimer disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11073858
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11073858
Other Identifiers
ISSN
1471-003X,1471-0048
E-ISSN
1471-0048,1469-3178
DOI
10.1038/s41583-023-00776-9
