Adjusting for common variant polygenic scores improves yield in rare variant association analyses
Adjusting for common variant polygenic scores improves yield in rare variant association analyses
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
With the emergence of large-scale sequencing data, methods for improving power in rare variant association tests are needed. Here we show that adjusting for common variant polygenic scores improves yield in gene-based rare variant association tests across 65 quantitative traits in the UK Biobank (up to 20% increase at
α
= 2.6 × 10
−6
)...
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Full title
Adjusting for common variant polygenic scores improves yield in rare variant association analyses
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11078202
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11078202
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-023-01342-w
