PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
About this item
Full title
Author / Creator
Morotti, Matteo , Grimm, Alizee J. , Hope, Helen Carrasco , Arnaud, Marion , Desbuisson, Mathieu , Rayroux, Nicolas , Barras, David , Masid, Maria , Murgues, Baptiste , Chap, Bovannak S. , Ongaro, Marco , Rota, Ioanna A. , Ronet, Catherine , Minasyan, Aspram , Chiffelle, Johanna , Lacher, Sebastian B. , Bobisse, Sara , Murgues, Clément , Ghisoni, Eleonora , Ouchen, Khaoula , Bou Mjahed, Ribal , Benedetti, Fabrizio , Abdellaoui, Naoill , Turrini, Riccardo , Gannon, Philippe O. , Zaman, Khalil , Mathevet, Patrice , Lelievre, Loic , Crespo, Isaac , Conrad, Marcus , Verdeil, Gregory , Kandalaft, Lana E. , Dagher, Julien , Corria-Osorio, Jesus , Doucey, Marie-Agnes , Ho, Ping-Chih , Harari, Alexandre , Vannini, Nicola , Böttcher, Jan P. , Dangaj Laniti, Denarda and Coukos, George
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Expansion of antigen-experienced CD8
+
T cells is critical for the success of tumour-infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer
1
. Interleukin-2 (IL-2) acts as a key regulator of CD8
+
cytotoxic T lymphocyte functions by promoting expansion and cytotoxic capability
2
,
3
. Theref...
Alternative Titles
Full title
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Authors, Artists and Contributors
Author / Creator
Grimm, Alizee J.
Hope, Helen Carrasco
Arnaud, Marion
Desbuisson, Mathieu
Rayroux, Nicolas
Barras, David
Masid, Maria
Murgues, Baptiste
Chap, Bovannak S.
Ongaro, Marco
Rota, Ioanna A.
Ronet, Catherine
Minasyan, Aspram
Chiffelle, Johanna
Lacher, Sebastian B.
Bobisse, Sara
Murgues, Clément
Ghisoni, Eleonora
Ouchen, Khaoula
Bou Mjahed, Ribal
Benedetti, Fabrizio
Abdellaoui, Naoill
Turrini, Riccardo
Gannon, Philippe O.
Zaman, Khalil
Mathevet, Patrice
Lelievre, Loic
Crespo, Isaac
Conrad, Marcus
Verdeil, Gregory
Kandalaft, Lana E.
Dagher, Julien
Corria-Osorio, Jesus
Doucey, Marie-Agnes
Ho, Ping-Chih
Harari, Alexandre
Vannini, Nicola
Böttcher, Jan P.
Dangaj Laniti, Denarda
Coukos, George
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11078736
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11078736
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-024-07352-w
