Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution...
Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Catalysis with engineered enzymes has provided more efficient routes for the production of active pharmaceutical agents. However, the potential of biocatalysis to assist in early-stage drug discovery campaigns remains largely untapped. In this study, we have developed a biocatalytic strategy for the construction of
sp
3
-rich polycyclic co...
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Full title
Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modelling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11088497
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11088497
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ISSN
1755-4330,1755-4349
E-ISSN
1755-4349
DOI
10.1038/s41557-023-01435-3
