ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Necroptosis is a lytic form of cell death that is mediated by the kinase RIPK3 and the pseudokinase MLKL when caspase-8 is inhibited downstream of death receptors, toll-like receptor 3 (TLR3), TLR4, and the intracellular Z-form nucleic acid sensor ZBP1. Oligomerization and activation of RIPK3 is driven by interactions with the kinase RIPK1, the TLR...
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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11093969
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11093969
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ISSN
1350-9047,1476-5403
E-ISSN
1476-5403
DOI
10.1038/s41418-024-01286-6
