Pivekimab sunirine (IMGN632), a novel CD123-targeting antibody–drug conjugate, in relapsed or refrac...
Pivekimab sunirine (IMGN632), a novel CD123-targeting antibody–drug conjugate, in relapsed or refractory acute myeloid leukaemia: a phase 1/2 study
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Author / Creator
Daver, Naval G, Prof , Montesinos, Pau, MD , DeAngelo, Daniel J, Prof , Wang, Eunice S, Prof , Papadantonakis, Nikolaos, MD , Todisco, Elisabetta, MD , Sweet, Kendra L, MD , Pemmaraju, Naveen, Prof , Lane, Andrew A, MD , Torres-Miñana, Laura, MD , Thompson, James E, MD , Konopleva, Marina Y, Prof , Sloss, Callum M, PhD , Watkins, Krystal, MS , Bedse, Gaurav, PhD , Du, Yining, PhD , Malcolm, Kara E, RN , Zweidler-McKay, Patrick A, MD and Kantarjian, Hagop M, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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More information
Scope and Contents
Contents
SummaryBackgroundPivekimab sunirine (IMGN632) is a first-in-class antibody–drug conjugate comprising a high-affinity CD123 antibody, cleavable linker, and novel indolinobenzodiazepine pseudodimer payload. CD123 is overexpressed in several haematological malignancies, including acute myeloid leukaemia. We present clinical data on pivekimab sunirine...
Alternative Titles
Full title
Pivekimab sunirine (IMGN632), a novel CD123-targeting antibody–drug conjugate, in relapsed or refractory acute myeloid leukaemia: a phase 1/2 study
Authors, Artists and Contributors
Author / Creator
Montesinos, Pau, MD
DeAngelo, Daniel J, Prof
Wang, Eunice S, Prof
Papadantonakis, Nikolaos, MD
Todisco, Elisabetta, MD
Sweet, Kendra L, MD
Pemmaraju, Naveen, Prof
Lane, Andrew A, MD
Torres-Miñana, Laura, MD
Thompson, James E, MD
Konopleva, Marina Y, Prof
Sloss, Callum M, PhD
Watkins, Krystal, MS
Bedse, Gaurav, PhD
Du, Yining, PhD
Malcolm, Kara E, RN
Zweidler-McKay, Patrick A, MD
Kantarjian, Hagop M, Prof
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11103591
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11103591
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(23)00674-5
