Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-depriv...
Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells
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Publisher
Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Contents
We investigated the role of autophagy, a controlled lysosomal degradation of cellular macromolecules and organelles, in glutamate excitotoxicity during nutrient deprivation in vitro. The incubation in low-glucose serum/amino acid-free cell culture medium synergized with glutamate in increasing AMP/ATP ratio and causing excitotoxic necrosis in SH-SY...
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Full title
Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11105051
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11105051
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ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-019-03356-2
