GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity
GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity
About this item
Full title
Author / Creator
Vila-Bedmar, Rocío , Cruces-Sande, Marta , Arcones, Alba C. , Willemen, Hanneke L. D. M. , Prieto, Patricia , Moreno-Indias, Isabel , Díaz-Rodríguez, Daniel , Francisco, Sara , Jaén, Rafael I. , Gutiérrez-Repiso, Carolina , Heijnen, Cobi J. , Boscá, Lisardo , Fresno, Manuel , Kavelaars, Annemieke , Mayor, Federico and Murga, Cristina
Publisher
Cham: Springer International Publishing
Journal title
Language
English
Formats
Publication information
Publisher
Cham: Springer International Publishing
Subjects
More information
Scope and Contents
Contents
Macrophages are key effector cells in obesity-associated inflammation. G protein-coupled receptor kinase 2 (GRK2) is highly expressed in different immune cell types. Using LysM-GRK2
+/−
mice, we uncover that a reduction of GRK2 levels in myeloid cells prevents the development of glucose intolerance and hyperglycemia after a high fat diet (HFD...
Alternative Titles
Full title
GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity
Authors, Artists and Contributors
Author / Creator
Cruces-Sande, Marta
Arcones, Alba C.
Willemen, Hanneke L. D. M.
Prieto, Patricia
Moreno-Indias, Isabel
Díaz-Rodríguez, Daniel
Francisco, Sara
Jaén, Rafael I.
Gutiérrez-Repiso, Carolina
Heijnen, Cobi J.
Boscá, Lisardo
Fresno, Manuel
Kavelaars, Annemieke
Mayor, Federico
Murga, Cristina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11105060
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11105060
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-019-03442-5
