Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system
Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system
About this item
Full title
Author / Creator
Song, Yuning , Yuan, Lin , Wang, Yong , Chen, Mao , Deng, Jichao , Lv, Qingyan , Sui, Tingting , Li, Zhanjun and Lai, Liangxue
Publisher
Cham: Springer International Publishing
Journal title
Language
English
Formats
Publication information
Publisher
Cham: Springer International Publishing
Subjects
More information
Scope and Contents
Contents
The CRISPR RNA-guided Cas9 nuclease gene-targeting system has been extensively used to edit the genome of several organisms. However, most mutations reported to date have been are indels, resulting in multiple mutations and numerous alleles in targeted genes. In the present study, a large deletion of 105 kb in the
TYR
(tyrosinase) gene was ge...
Alternative Titles
Full title
Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11108552
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11108552
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-016-2143-z
