Energy dysfunction in Huntington’s disease: insights from PGC-1α, AMPK, and CKB
Energy dysfunction in Huntington’s disease: insights from PGC-1α, AMPK, and CKB
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Publisher
Basel: Springer-Verlag
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Language
English
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Basel: Springer-Verlag
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Scope and Contents
Contents
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG trinucleotide expansion in the Huntingtin (Htt) gene. When the number of CAG repeats exceeds 36, the translated polyglutamine-expanded Htt protein interferes with the normal functions of many types of cellular machinery and causes cytotoxicity. Clinical sym...
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Full title
Energy dysfunction in Huntington’s disease: insights from PGC-1α, AMPK, and CKB
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11115139
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11115139
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-012-1025-2
