Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity
Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity
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Publisher
Basel: Birkhäuser-Verlag
Journal title
Language
English
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Publisher
Basel: Birkhäuser-Verlag
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Contents
.
Inhibiting the production of amyloid-β by antagonising γ-secretase activity is currently being pursued as a therapeutic strategy for Alzheimer’s disease (AD). However, early pre-clinical studies have demonstrated that disruption of presenilin-dependent γ-secretase alters many presenilin-dependent processes, leading to early lethality in severa...
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Full title
Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11131470
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11131470
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-009-8435-9
