Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradic...
Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication
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Publisher
Oxford, UK: Blackwell Publishing Ltd
Journal title
Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Scope and Contents
Contents
The adaptor protein ASC (also called TMS1) links certain NLR proteins (e.g., NLRC4, NLRP3) and caspases. It is involved in the chemosensitivity of tumor cells and inflammation. Here, we found that ASC activation using NLRC4 mimicry or an autoinflammatory disease‐associated NLRP3 mutant induced necrosis in COLO205 colon adenocarcinoma cells, but ind...
Alternative Titles
Full title
Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11159384
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11159384
Other Identifiers
ISSN
1347-9032,1349-7006
E-ISSN
1349-7006
DOI
10.1111/j.1349-7006.2010.01610.x
