SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with predia...
SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes
About this item
Full title
Author / Creator
Sabadell-Basallote, Joan , Astiarraga, Brenno , Castaño, Carlos , Ejarque, Miriam , Repollés-de-Dalmau, Maria , Quesada, Ivan , Blanco, Jordi , Núñez-Roa, Catalina , Rodríguez-Peña, M-Mar , Martínez, Laia , De Jesus, Dario F. , Marroquí, Laura , Bosch, Ramon , Montanya, Eduard , Sureda, Francesc X. , Tura, Andrea , Mari, Andrea , Kulkarni, Rohit N. , Vendrell, Joan and Fernández-Veledo, Sonia
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Pancreatic β cell dysfunction is a key feature of type 2 diabetes, and novel regulators of insulin secretion are desirable. Here, we report that succinate receptor 1 (SUCNR1) is expressed in β cells and is upregulated in hyperglycemic states in mice and humans. We found that succinate acted as a hormone-like metabolite and stimulated insulin secret...
Alternative Titles
Full title
SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes
Authors, Artists and Contributors
Author / Creator
Astiarraga, Brenno
Castaño, Carlos
Ejarque, Miriam
Repollés-de-Dalmau, Maria
Quesada, Ivan
Blanco, Jordi
Núñez-Roa, Catalina
Rodríguez-Peña, M-Mar
Martínez, Laia
De Jesus, Dario F.
Marroquí, Laura
Bosch, Ramon
Montanya, Eduard
Sureda, Francesc X.
Tura, Andrea
Mari, Andrea
Kulkarni, Rohit N.
Vendrell, Joan
Fernández-Veledo, Sonia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11178533
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11178533
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI173214
